Mile-a-minute weed (Mikania micrantha H.B.K), a fast growing herbaceous climber, is a noxious weed in agricultural and non-agricultural areas of Kerala, India. The allelopathic effects of M. micrantha when used as fresh mulch, incorporated in soil and as water extracts of the weed (0, 1, 2 and 4 percent) were studied using test crops (cowpea, rubber and rice). M. micrantha had negative allelopathy on rubber (Hevea brasiliensis) seedlings, causing reduction in height and weight of seedlings. On the contrary, it had positive allelopathy on growth of rice and neutral effect on growth of cowpea. The study indicated that the infestation of M. micrantha in rubber plantation or in nursery may have deleterious effect on growth of H. brasiliensis. It also showed that this weed can be utilized as green leaf manure for rice without any adverse effect on the crop.